LPS decrease KCC2 expression in primary rat cerebral cortex cells and PC-12 cells
نویسندگان
چکیده
منابع مشابه
Protective effect of adult olfactory ensheathing cells against 6-OHDA toxicity in PC-12 cells
Olfactory ensheathing cells (OEC) have been successfully used to stimulate the growth of injured fibers and to promote functional recovery within the injured adult CNS. These cells exhibit functional properties, which are known to be involved in axonal elongation. OEC express high level of growth factors including NGF, GDNF, BDNF and NT-3, which are known to play an important role in nerve rege...
متن کاملProtective effect of adult olfactory ensheathing cells against 6-OHDA toxicity in PC-12 cells
Olfactory ensheathing cells (OEC) have been successfully used to stimulate the growth of injured fibers and to promote functional recovery within the injured adult CNS. These cells exhibit functional properties, which are known to be involved in axonal elongation. OEC express high level of growth factors including NGF, GDNF, BDNF and NT-3, which are known to play an important role in nerve rege...
متن کاملDetection of IL-20R1 and IL-20R2 mRNA in C57BL/6 Mice Astroglial Cells and Brain Cortex Following LPS Stimulation
Background: Astrocytes, which comprise ~90% of overall brain mass, are involved in brain immunity. These cells represent the non-professional class of CNS-resident APCs and may promote or inhibit CNS inflammation depending on the cytokines they secrete. IL-10 family of cytokines and their receptors, IL-20R1 and IL-20R2, may have a role in shifting astrocytes to a neuroprotective or neurodegener...
متن کاملKetamine Metabolites Enantioselectively Decrease Intracellular D-Serine Concentrations in PC-12 Cells.
D-Serine is an endogenous NMDA receptor co-agonist that activates synaptic NMDA receptors modulating neuronal networks in the cerebral cortex and plays a key role in long-term potentiation of synaptic transmission. D-serine is associated with NMDA receptor neurotoxicity and neurodegeneration and elevated D-serine concentrations have been associated with Alzheimer's and Parkinsons' diseases and ...
متن کاملreduction of no production in lps-stimulated primary rat microglial cells by bromelain
microglia, the sentries of the brain, is highly implicated in neurodegeneration as in neuroprotection. chronic microglial activation endangers neuronal survival through the release of various potentially neurotoxic mediators including nitric oxide (no). thus, negative regulators of microglial activation have been considered as potential therapeutic candidates to target neurodegeneration, such a...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2021
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.94.0_2-p1-18